Cayman Chemical PD-L1/CD274兔单克隆抗体背景：

程序性细胞死亡配体1（PD-L1），也称为B7-H1或CD274，是一种B7家族蛋白，参与调节和减弱适应性免疫应答和外周T细胞耐受性。1、2、3、4它是一种290个氨基酸的I型跨膜蛋白，在人类中由CD274编码，一个IgV样结构域，一个IgC样结构域、一个跨膜结构域和一个细胞质尾部。PD-L1在T和B细胞、树突状细胞、巨噬细胞和调节性T细胞（Tregs）以及多种非造血细胞中组成性表达，并被IFN-γ上调，抑制T细胞增殖、迁移和细胞因子产生。PD-L1也在多种肿瘤细胞中异常表达，肿瘤组织中PD-L1的表达与肾细胞癌患者的不良预后相关。含有PD-L1阻断抗体的制剂已用于治疗多种癌症。Cayman的PD-L1/CD274兔单克隆抗体（APC）由与别藻蓝蛋白（APC）缀合的PD-L1/CD274单克隆抗体组成，可用于流式细胞术。

Cayman Chemical PD-L1/CD274兔单克隆抗体技术参数：

免疫原：重组小鼠PD-L1

配方：蛋白A亲和纯化单克隆抗体

宿主：兔子

同种型：IgG抗体

应用：FC、Cross Reactivity、(+) PD-L1

存储：4摄氏度

稳定性：≥1年

Cayman Chemical艾美捷PD-L1/CD274兔单克隆抗体文献：

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